Patrick J. La Riviere

Associate Professor
Research Summary
My lab develops algorithms and algorithm-enabled imaging systems at scales from nanometers (x-ray microscopy) to meters (human computed tomography). Themes that span all scales and modalities include dose reduction, material identification, and orientation imaging.
Computed Tomography, X-Ray, Computational Imaging, Microscopy, Fluorescence, X-Ray Fluorescence Spectroscopy
  • Harvard University, Cambridge, MA, A.B. Physics 06/1994
  • Cambridge University, Cambridge, UK, Philosophy of physics 06/1995
  • University of Chicago, Chicago, IL, Ph.D. Medical Physics 12/2000
Biosciences Graduate Program Association
Awards & Honors
  • 1994 - Lionel deJersey Harvard Scholarship to Cambridge University Harvard University
  • 2005 - Young Investigator Medical Imaging Scientist Award IEEE
  • 2016 - Fellow Marine Biological Laboratory
  • 2018 - Distinguished investigator Academy for Radiology and Biomedical Imaging Research
  1. Colón-Ramos DA, La Riviere P, Shroff H, Oldenbourg R. Transforming the development and dissemination of cutting-edge microscopy and computation. Nat Methods. 2019 08; 16(8):667-669. View in: PubMed

  2. Ding Y, Vanselow DJ, Yakovlev MA, Katz SR, Lin AY, Clark DP, Vargas P, Xin X, Copper JE, Canfield VA, Ang KC, Wang Y, Xiao X, De Carlo F, van Rossum DB, La Riviere P, Cheng KC. Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography. Elife. 2019 05 07; 8. View in: PubMed

  3. Ni K, Lan G, Chan C, Quigley B, Lu K, Aung T, Guo N, La Riviere P, Weichselbaum RR, Lin W. Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy. Nat Commun. 2018 06 15; 9(1):2351. View in: PubMed

  4. Coates MI, Finarelli JA, Sansom IJ, Andreev PS, Criswell KE, Tietjen K, Rivers ML, La Riviere PJ. An early chondrichthyan and the evolutionary assembly of a shark body plan. Proc Biol Sci. 2018 01 10; 285(1870). View in: PubMed

  5. Chandler T, Mehta S, Shroff H, Oldenbourg R, La Rivière PJ. Single-fluorophore orientation determination with multiview polarized illumination: modeling and microscope design. Opt Express. 2017 Dec 11; 25(25):31309-31325. View in: PubMed

  6. Wu Y, Kumar A, Smith C, Ardiel E, Chandris P, Christensen R, Rey-Suarez I, Guo M, Vishwasrao HD, Chen J, Tang J, Upadhyaya A, La Riviere PJ, Shroff H. Reflective imaging improves spatiotemporal resolution and collection efficiency in light sheet microscopy. Nat Commun. 2017 11 13; 8(1):1452. View in: PubMed

  7. Day KJ, La Rivière PJ, Chandler T, Bindokas VP, Ferrier NJ, Glick BS. Improved deconvolution of very weak confocal signals. F1000Res. 2017; 6:787. View in: PubMed

  8. Quigley BP, Smith CD, Cheng SH, Souris JS, Pelizzari CA, Chen CT, Lo LW, Reft CS, Wiersma RD, La Riviere PJ. Sensitivity evaluation and selective plane imaging geometry for x-ray-induced luminescence imaging. Med Phys. 2017 Oct; 44(10):5367-5377. View in: PubMed

  9. Pan X, Siewerdsen J, La Riviere PJ, Kalender WA. Anniversary Paper: Development of x-ray computed tomography: The role of Medical Physics and AAPM from the 1970s to present. Med Phys. 2008 Aug; 35(8):3728-3739. View in: PubMed

  10. Modgil D, Bindschadler MD, Alessio AM, La Rivière PJ. Variable temporal sampling and tube current modulation for myocardial blood flow estimation from dose-reduced dynamic computed tomography. J Med Imaging (Bellingham). 2017 Apr; 4(2):026002. View in: PubMed

  11. Rigie DS, Sanchez AA, La Rivière PJ. Assessment of vectorial total variation penalties on realistic dual-energy CT data. Phys Med Biol. 2017 04 21; 62(8):3284-3298. View in: PubMed

  12. Wu Y, Chandris P, Winter PW, Kim EY, Jaumouillé V, Kumar A, Guo M, Leung JM, Smith C, Rey-Suarez I, Liu H, Waterman CM, Ramamurthi KS, La Riviere PJ, Shroff H. Simultaneous multiview capture and fusion improves spatial resolution in wide-field and light-sheet microscopy. Optica. 2016 Aug 20; 3(8):897-910. View in: PubMed

  13. Mehta SB, McQuilken M, La Riviere PJ, Occhipinti P, Verma A, Oldenbourg R, Gladfelter AS, Tani T. Dissection of molecular assembly dynamics by tracking orientation and position of single molecules in live cells. Proc Natl Acad Sci U S A. 2016 10 18; 113(42):E6352-E6361. View in: PubMed

  14. Rigie DS, La Rivière PJ. Optimizing spectral CT parameters for material classification tasks. Phys Med Biol. 2016 06 21; 61(12):4599-622. View in: PubMed

  15. Bindschadler M, Modgil D, Branch KR, La Riviere PJ, Alessio AM. Evaluation of static and dynamic perfusion cardiac computed tomography for quantitation and classification tasks. J Med Imaging (Bellingham). 2016 Apr; 3(2):024001. View in: PubMed

  16. Groll A, George J, Vargas P, La Rivière PJ, Meng LJ. Element Mapping in Organic Samples Utilizing a Benchtop X-Ray Fluorescence Emission Tomography (XFET) System. IEEE Trans Nucl Sci. 2015 Oct; 62(5):2310-2317. View in: PubMed

  17. Modgil D, Rigie DS, Wang Y, Xiao X, Vargas PA, La Rivière PJ. Material identification in x-ray microscopy and micro CT using multi-layer, multi-color scintillation detectors. Phys Med Biol. 2015 Oct 21; 60(20):8025-45. View in: PubMed

  18. Little KJ, La Rivière PJ. Sinogram restoration in computed tomography with an edge-preserving penalty. Med Phys. 2015 Mar; 42(3):1307-20. View in: PubMed

  19. Rigie DS, La Rivière PJ. Joint reconstruction of multi-channel, spectral CT data via constrained total nuclear variation minimization. Phys Med Biol. 2015 Mar 07; 60(5):1741-62. View in: PubMed

  20. Modgil D, Alessio AM, Bindschadler MD, La Rivière PJ. Sinogram smoothing techniques for myocardial blood flow estimation from dose-reduced dynamic computed tomography. J Med Imaging (Bellingham). 2014 Nov 03; 1(3):034004. View in: PubMed

  21. Souris JS, Cheng SH, Pelizzari C, Chen NT, La Riviere P, Chen CT, Lo LW. Radioluminescence characterization of in situ x-ray nanodosimeters: Potential real-time monitors and modulators of external beam radiation therapy. Appl Phys Lett. 2014 Nov 17; 105(20):203110. View in: PubMed

  22. Bindschadler M, Modgil D, Branch KR, La Riviere PJ, Alessio AM. Simulation Evaluation of Quantitative Myocardial Perfusion Assessment from Cardiac CT. Proc SPIE Int Soc Opt Eng. 2014 Mar 19; 9033:903303. View in: PubMed

  23. Athanassiadis AG, La Rivière PJ, Sidky E, Pelizzari C, Pan X, Jaeger HM. X-ray tomography system to investigate granular materials during mechanical loading. Rev Sci Instrum. 2014 Aug; 85(8):083708. View in: PubMed

  24. Bindschadler M, Modgil D, Branch KR, La Riviere PJ, Alessio AM. Comparison of blood flow models and acquisitions for quantitative myocardial perfusion estimation from dynamic CT. Phys Med Biol. 2014 Apr 07; 59(7):1533-56. View in: PubMed

  25. Fu G, Meng LJ, Eng P, Newville M, Vargas P, La Riviere P. Experimental demonstration of novel imaging geometries for x-ray fluorescence computed tomography. Med Phys. 2013 Jun; 40(6):061903. View in: PubMed

  26. Petschke A, La Rivière PJ. Comparison of photoacoustic image reconstruction algorithms using the channelized Hotelling observer. J Biomed Opt. 2013 Feb; 18(2):26009. View in: PubMed

  27. La Rivière PJ, Bian J, Vargas PA. Comparison of quadratic- and median-based roughness penalties for penalized-likelihood sinogram restoration in computed tomography. Int J Biomed Imaging. 2006; 2006:41380. View in: PubMed

  28. Yu H, La Rivière PJ, Tang X. Development of computed tomography algorithms. Int J Biomed Imaging. 2006; 2006:39397. View in: PubMed

  29. Modgil D, Treeby BE, La Rivière PJ. Photoacoustic image reconstruction in an attenuating medium using singular-value decomposition. J Biomed Opt. 2012 Jun; 17(6):061204. View in: PubMed

  30. Meng LJ, Li N, La Riviere PJ. X-ray Fluorescence Emission Tomography (XFET) with Novel Imaging Geometries - A Monte Carlo Study. IEEE Trans Nucl Sci. 2011 Dec; 58(6):3359-3369. View in: PubMed

  31. Leoni L, Dhyani A, La Riviere P, Vogt S, Lai B, Roman BB. ß-Cell subcellular localization of glucose-stimulated Mn uptake by X-ray fluorescence microscopy: implications for pancreatic MRI. Contrast Media Mol Imaging. 2011 Nov-Dec; 6(6):474-81. View in: PubMed

  32. Cheng KC, Xin X, Clark DP, La Riviere P. Whole-animal imaging, gene function, and the Zebrafish Phenome Project. Curr Opin Genet Dev. 2011 Oct; 21(5):620-9. View in: PubMed

  33. Vargas PA, La Rivière PJ. Comparison of sinogram- and image-domain penalized-likelihood image reconstruction estimators. Med Phys. 2011 Aug; 38(8):4811-23. View in: PubMed

  34. Mathew B, Jacobson JR, Berdyshev E, Huang Y, Sun X, Zhao Y, Gerhold LM, Siegler J, Evenoski C, Wang T, Zhou T, Zaidi R, Moreno-Vinasco L, Bittman R, Chen CT, LaRiviere PJ, Sammani S, Lussier YA, Dudek SM, Natarajan V, Weichselbaum RR, Garcia JG. Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs. FASEB J. 2011 Oct; 25(10):3388-400. View in: PubMed

  35. Petschke A, La Rivière PJ. Comparison of intensity-modulated continuous-wave lasers with a chirped modulation frequency to pulsed lasers for photoacoustic imaging applications. Biomed Opt Express. 2010 Oct 20; 1(4):1188-1195. View in: PubMed

  36. Forthmann P, Koehler T, Defrise M, La Riviere P. Comparing implementations of penalized weighted least-squares sinogram restoration. Med Phys. 2010 Nov; 37(11):5929-38. View in: PubMed

  37. Mathew B, Lennon FE, Siegler J, Mirzapoiazova T, Mambetsariev N, Sammani S, Gerhold LM, LaRiviere PJ, Chen CT, Garcia JG, Salgia R, Moss J, Singleton PA. The novel role of the mu opioid receptor in lung cancer progression: a laboratory investigation. Anesth Analg. 2011 Mar; 112(3):558-67. View in: PubMed

  38. Modgil D, La Riviére PJ. Optimizing wavelength choice for quantitative optoacoustic imaging using the Cramer-Rao lower bound. Phys Med Biol. 2010 Dec 07; 55(23):7231-51. View in: PubMed

  39. Mathew B, Huang Y, Jacobson JR, Berdyshev E, Gerhold LM, Wang T, Moreno-Vinasco L, Lang G, Zhao Y, Chen CT, LaRiviere PJ, Mauceri H, Sammani S, Husain AN, Dudek SM, Natarajan V, Lussier YA, Weichselbaum RR, Garcia JG. Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):415-22. View in: PubMed

  40. Green AH, Norris JR, Wang J, Xie Z, Zhang HF, La Riviere PJ. In vitro testing of a protease-sensitive contrast agent for optoacoustic imaging. J Biomed Opt. 2010 Mar-Apr; 15(2):021315. View in: PubMed

  41. Modgil D, Anastasio MA, La Rivière PJ. Image reconstruction in photoacoustic tomography with variable speed of sound using a higher-order geometrical acoustics approximation. J Biomed Opt. 2010 Mar-Apr; 15(2):021308. View in: PubMed

  42. La Riviere P, Vargas P, Xia D, Pan X. Region of interest reconstruction in x-ray fluorescence computed tomography for negligible attenuation. IEEE Trans Nucl Sci. 2010 Feb 01; 57(1):234-241. View in: PubMed

  43. Zhang J, Anastasio MA, La Riviere PJ, Wang LV. Effects of different imaging models on least-squares image reconstruction accuracy in photoacoustic tomography. IEEE Trans Med Imaging. 2009 Nov; 28(11):1781-90. View in: PubMed

  44. Modgil D, La Rivière PJ. Implementation and comparison of reconstruction algorithms for two-dimensional optoacoustic tomography using a linear array. J Biomed Opt. 2009 Jul-Aug; 14(4):044023. View in: PubMed

  45. Sandhu JS, Schmidt RA, La Rivière PJ. Full-field acoustomammography using an acousto-optic sensor. Med Phys. 2009 Jun; 36(6):2324-7. View in: PubMed

  46. La Rivière PJ, Vargas P. Correction for resolution nonuniformities caused by anode angulation in computed tomography. IEEE Trans Med Imaging. 2008 Sep; 27(9):1333-41. View in: PubMed

  47. Pan X, Siewerdsen J, La Riviere PJ, Kalender WA. Anniversary paper. Development of x-ray computed tomography: the role of medical physics and AAPM from the 1970s to present. Med Phys. 2008 Aug; 35(8):3728-39. View in: PubMed

  48. La Rivière PJ, Vargas PA. Monotonic penalized-likelihood image reconstruction for X-ray fluorescence computed tomography. IEEE Trans Med Imaging. 2006 Sep; 25(9):1117-29. View in: PubMed

  49. La Rivière PJ, Bian J, Vargas PA. Penalized-likelihood sinogram restoration for computed tomography. IEEE Trans Med Imaging. 2006 Aug; 25(8):1022-36. View in: PubMed

  50. La Rivière PJ, Zhang J, Anastasio MA. Image reconstruction in optoacoustic tomography for dispersive acoustic media. Opt Lett. 2006 Mar 15; 31(6):781-3. View in: PubMed

  51. La Rivière PJ. Penalized-likelihood sinogram smoothing for low-dose CT. Med Phys. 2005 Jun; 32(6):1676-83. View in: PubMed

  52. La Rivière PJ, Billmire DM. Reduction of noise-induced streak artifacts in X-ray computed tomography through spline-based penalized-likelihood sinogram smoothing. IEEE Trans Med Imaging. 2005 Jan; 24(1):105-11. View in: PubMed

  53. La Rivière PJ. Approximate analytic reconstruction in x-ray fluorescence computed tomography. Phys Med Biol. 2004 Jun 07; 49(11):2391-405. View in: PubMed

  54. La Rivière PJ, Pan X. Sampling and aliasing consequences of quarter-detector offset use in helical CT. IEEE Trans Med Imaging. 2004 Jun; 23(6):738-49. View in: PubMed

  55. Armato SG, Altman MB, La Rivière PJ. Automated detection of lung nodules in CT scans: effect of image reconstruction algorithm. Med Phys. 2003 Mar; 30(3):461-72. View in: PubMed

  56. La Rivière PJ, Pan X. Longitudinal aliasing in multislice helical computed tomography: sampling and cone-beam effects. IEEE Trans Med Imaging. 2002 Nov; 21(11):1366-73. View in: PubMed

  57. La Rivière PJ, Pan X. Anti-aliasing weighting functions for single-slice helical CT. IEEE Trans Med Imaging. 2002 Aug; 21(8):978-90. View in: PubMed

  58. La Rivière PJ, Pan X. Pitch dependence of longitudinal sampling and aliasing effects in multi-slice helical computed tomography (CT). Phys Med Biol. 2002 Aug 07; 47(15):2797-810. View in: PubMed

  59. La Rivière PJ, Pan X. Favorable noise uniformity properties of Fourier-based interpolation and reconstruction approaches in single-slice helical computed tomography. Med Phys. 2002 Jun; 29(6):943-51. View in: PubMed

  60. La Rivière PJ, Pan X. Fourier-based approach to interpolation in single-slice helical computed tomography. Med Phys. 2001 Mar; 28(3):381-92. View in: PubMed

  61. La Rivière PJ, Pan X. Nonparametric regression sinogram smoothing using a roughness-penalized Poisson likelihood objective function. IEEE Trans Med Imaging. 2000 Aug; 19(8):773-86. View in: PubMed