Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue

Aug 4, 2020
By Inna Gertsenshteyn, Mihai Giurcanu, Peter Vaupel, Howard Halpern
Credit: Wiley

Measuring molecular oxygen levels in vivo has been the cornerstone of understanding the effects of hypoxia in normal tissues and malignant tumors. Here we discuss the advances in a variety of partial pressure of oxygen (tjp14197-math-0001) measurements and imaging techniques and relevant oxygen thresholds. A focus on electron paramagnetic resonance (EPR) imaging shows the validation of treating hypoxic tumours with a threshold of tjp14197-math-0002 ≤ 10 Torr, and demonstrates utility for in vivo oxygen imaging, as well as its current and future role in cancer studies.